Fig. 1
From: Exploring pathway interactions to detect molecular mechanisms of disease: 22q11.2 deletion syndrome
Pathway Interaction Network. Figure 1A represents the significant path network of the Psychiatric Group, and Fig. 1B the network of the Nonpsychiatric Group. Downregulated nodes were colored blue, upregulated red. The source node (yellow, labeled 22q11DS) was colored yellow. Figure 1A shows several hubs such as CRKL, PDGFRB, GRAP2, and SNAP29, while Fig. 1B has CEACAM8, SNAP29, KLHL22, and OLR1 as most connected nodes. The genes that are known to be directly affected by the deletion, i.e., members of the 22q11DS pathway, are first neighbours of the source node and are marked with red arrows