Table 4 Study predictive relationships reported

Spinelli et al. [9]

Univariate Cox analysis with predictor variable thresholds established by ROC curve analysis

NR

Predictors of events*:

LVMI (g/h^2.7) > 54.3: 1.022 (1.008–1.036), p = 0.002

eGFR ≤ 69: 0.978 (0.961–0.996), p = 0.016

Graziani et al. [6, 15]

Univariate and multivariate Cox regressions

NR

Predictors of events*:

eGFR: 0.97 (0.95–0.99), p 0.008

LVMI (g/m²) (univariate): 1.01 (1.00–1.01) p < 0.001

LVMI (g/m²) (multivariate): 1.01 (1.00–1.03) p = 0.03

Hanneman et al. [8, 16]

Univariate and multivariate Cox regressions

NR

HR for 5 g/m² increase in LVMI

1.1 (1.1–1.2), p < 0.001 (univariate)

1.1 (1.04–1.2), p < 0.001 (multivariate)

Feriozzi et al. [12, 18]

Multivariate Cox regression analysis

NR

HR for cardiovascular event

LVMI (g/h^2.7) at baseline (abnormal vs normal*) 1.57 (1.21–2.05) p < 0.001

eGFR at baseline (abnormal vs normal) 1.33 (1.04–1.70) p = 0.021

HR for renal event

LVMI (g/h^2.7) at baseline (abnormal* vs normal) 1.90 (0.94–3.85) p = 0.074

eGFR at baseline (abnormal* vs normal) 5.88 (2.73–12.68) p < 0.001

* Abnormal LVMI defined as > 50 g/h^2.7 in males and > 48 g/m^2.7 in females; abnormal eGFR defined as < 90 mL/min/1.73 m²

Lenders et al. [10]

Cox proportional hazards model

NR

Patients without endpoints had an average eGFR at baseline of 102.6 (± 26.6) compared to 71.3 (± 28.1)

HR for endpoint-free survival of on ERT patients with an eGFR =  < 75 mL/min/1.73 m²: 4.77 (1.93–11.81), p < 0.001

HR for cardiovascular endpoints after ERT initiation endpoint-free survival for patients with an eGFR ≤ 75 mL/min/1.73 m²: 3.59 (1.15–11.18); p = 0.03

Siegenthaler et al. [13, 17]^†

Univariate and multivariate Cox regressions

NR

HR for occurrence of primary endpoint per SD increase in LVMMI: Crude (2.14, CI 1.52–3.01, p < 0.001), Model 1 (1.65, CI 1.06–2.58, p = 0.03), Model 2 (1.67, CI 1.04–2.73, p = 0.03), Model 3 (1.67, CI 1.04–2.73, p = 0.03)

HR for occurrence of primary endpoint per SD increase in eGFR: Crude (0.42, CI 0.28–0.61, p < 0.001), Model 1 (0.45, CI 0.27–0.74, p = 0.002), Model 2 (0.42, CI 0.24–0.74, p = 0.003), Model 3 (0.45, CI 0.25–0.83, p = 0.01)

HR for occurrence of primary endpoint for patients with eGFR < 90 mL/min/1.73 m² at baseline, Crude (6.38 CI 1.91–21.33 p = 0.003) Model 1 (4.3 CI 1.06–17.52 p = 0.04) Model 2 (4.88 CI 1.12–21.24) Model 3 (4.41 CI 0.97–20.06)

HR for occurrence of primary endpoint for patients with LVMMI > 107 g/m² at baseline, Crude (4.28, CI 1.58–11.56 p = 0.004), Model 1 (1.79, CI 0.55–5.82 p = 0.37), Model 2 (1.83, CI 0.56–5.97 p = 0.32), Model 3 (1.75 CI 0.54–5.69 p = 0.35)

Higher LVMMI and lower eGFR at baseline associated with a greater risk of developing an adverse clinical event (HR 2.21 [1.43–3.42], p < 0.001 for LVMMI, HR 0.41 [0.27–0.62], p < 0.001 for eGFR) (per SD increase in LVMMI and SD decrease in eGFR)—Excluding atrial fibrillation

Crude model contained only LVMMI/eGFR as predictor, Model 1 included age and gender, Model 2: Model 1 + transplant status, dialysis status and Model 3: Model 2 + hypertension status and baseline LVMMI/eGFR

Patel et al. [11]

Univariate logistic regression models, eGFR not considered in multivariate model as not selected during stepwise selection

OR of experiencing a CV event for patients with low eGFR (< 60 mL/min/1.73 m²)

Men OR: 2.33 (1.22–4.45), p < 0.05

Women OR: 3.85 (1.78–8.32), p < 0.0001

NR

Arends et al. [5, 14]

Univariate and multivariate Cox regressions

NR

HRs of the additional potential prognostic variables on the clinical event rate, adjusted for age at start of ERT, sex and phenotype

Mixed-effect models

eGFR (per −10 mL/min/1.73 m²) HR: 1.19 (1.11–1.27), p < 0.001

eGFR < 60 mL/min/1.73 m² HR: 3.58 (2.21–6.05), p < 0.001

LVMI (per 10 g/m^2.7) HR: 1.25 (1.08–1.45), p < 0.01

Multivariate

eGFR (per −10 mL/min/1.73 m²) HR: 1.12 (1.03–1.22), p < 0.01

LVMI (per 10 g/m^2.7) HR: 1.16 (0.99–1.36), p > 0.05

Multivariate analysis with eGFR as dichotomous variable

eGFR (< 60 mL/min/1.73 m²) 2.66, CI 1.45–4.90, p = 0.002

LVMI (per 10 g/m^2.7) 1.19, CI 1.02–1.38, p = 0.028

Multivariate analysis, excluding renal events

eGFR (per -10 mL/min/1.73 m²) 1.01, CI 0.93–1.10, p = 0.78

LVMI (per 10 g/m^2.7) 1.19, CI 1.02–1.38, p = 0.03