Fig. 1From: Challenges in the care of individuals with severe primary insulin-like growth factor-I deficiency (SPIGFD): an international, multi-stakeholder perspectiveSPIGFD disease pathway. *The liver is the main producer of circulating IGF-I; however, GH-stimulated IGF-I production also occurs in multiple tissues. GH, growth hormone; GHR, growth hormone receptor; IGF-I, insulin-like growth factor; SPIGFD, severe primary IGF-I deficiencyBack to article page