Table 1 Model parameters

NI: Log-normal PFS survival mode

λ = 1.93843, γ = 1.26135

–

–

[10]

C: Log-logistic PFS survival mode

λ = 7.53780, γ = 2.29427

–

–

[10]

NI: OS survival mode

 NI-A: WeibullPH OS survival mode

λ = 0.0241553, γ = 1.1284343

–

–

[10]

 NI-E: Log-logistic OS survival mode

λ = 19.01452, γ = 1.51241

–

–

[10]

 NI-N: Exponential OS survival mode

λ = 0.0412831

–

–

[10]

C: OS survival mode

 C-A: Log-logistic OS survival mode

λ = 14.25065, γ = 1.76236

–

–

[10]

 C-E: Log-logistic OS survival mode

λ = 16.70245, γ = 1.70694

–

–

[10]

 C-N: Log-logistic OS survival mode

λ = 9.03382, γ = 2.1$77.96 1

–

–

[10]

NI: Incidence of AEs, %

 Asthenia

0

–

–

[10]

 Anemia

0.33

0.27

0.40

[10]

 Neutropenia

0.67

0.53

0.80

[10]

C: Incidence of AEs, %

 Asthenia

4.20

3.36

5.04

[10]

 Anemia

11.27

9.02

13.52

[10]

 Neutropenia

15.14

12.11

18.17

[10]

Utility

 PFS

0.706

0.565

0.847

[19]

 PD

0.565

0.452

0.678

[19]

 Death

0

–

–

[19]

 Asthenia

 − 0.07

 − 0.04

 − 0.11

[20]

 Anemia

 − 0.073

 − 0.037

 − 0.110

[21]

 Neutropenia

 − 0.20

 − 0.15

 − 0.25

[21]

Drug cost per mg, USD

 Nivolumab

15.96

6.44

19.16

[13]

 Ipilimumab

77.96

38.98

93.55

[13]

 Pemetrexed

0.88

0.05

6.40

[13]

 Cisplatin

0.12

0.01

0.83

[13]

 Carboplatin

0.09

0.02

0.33

[13]

 Vinorelbine

1.52

0.06

5.61

[13]

 Gemcitabine

0.07

 < 0.01

0.36

[13]

Administration IV, first hour, USD

7.83

6.27

9.40

[22]

Outpatient follow-up visit, per cycle, USD

69.13

51.85

86.29

[23]

AEs cost per 1-month cycle, first cycle only, USD

 Asthenia

96.05

67.24

124.87

[24]

 Anemia

500.78

445.76

545.54

[21]

 Neutropenia

434.57

0.00

1,290.65

[21]

Body area surface/m²

1.72

1.50

1.90

[18]

Weight/kg

65.00

48.75

81.25

[18]

Creatinine clearance/mL min⁻¹

60

–

–

[18]

Discount rate

0.05

0

0.08

[25]