Pharmacovigilance for rare diseases: a bibliometrics and knowledge-map analysis based on web of science

Table 6 The top 25 high-frequency keywords

Rank	Keywords	Count	Centrality	Rank	Keywords	Count	Centrality
1	clinical trial	101	0.37	14	patient	15	0.03
2	therapy	62	0.23	15	chemotherapy	14	0.02
3	adverse event	52	0.32	16	gene therapy	13	0.06
4	management	51	0.15	17	guideline	13	0.02
5	rare diseases	45	0.11	18	enzyme replacement therapy	12	0.01
6	efficacy	43	0.09	19	interstitial lung disease	11	0.04
7	adverse drug reaction	39	0.23	20	mutation	10	0.05
8	diagnosis	39	0.09	21	antibody	10	0.02
9	children	30	0.14	22	treatment outcome	10	0.02
10	disease	27	0.12	23	cancer	10	0.01
11	safety	24	0.04	24	follow up	10	0.01
12	risk	17	0.05	25	nivolumab	10	0
13	quality of life	17	0.03

ISSN: 1750-1172