Table 1 Detailed search strategy in this study
Set | Result | Search query |
|---|---|---|
1 | 31,445 | (((((((TS=(“rare disease*”)) OR TS=(“rare disorder*”)) OR TS=(“orphan disease*”)) OR TS=(“infrequent disease*”)) OR TS=(“seldom disease*”)) OR TS=(“ultra-rare disease*”)) OR TS=(“orphan* drug*”)) OR TS=(“orphan* medicinal”) |
2 | 82,125 | (((TS=(“rare” NEAR/5 “disease*”)) OR TS=(“rare” NEAR/5 “disorder*”)) OR TS=(“orphan*” NEAR/5 “disease*”)) OR TS=(“orphan” NEAR/5 “drug*”) |
3 | 82,298 | #1 OR #2 |
4 | 242,617 | ((((((TS=(“Pharmacovigilance”)) OR TS= (“adverse drug* reaction*”)) OR TS= (“adverse reaction*”)) OR TS= (“adverse drug* effect*”)) OR TS= (“adverse event*”)) OR TS= (“adverse drug* event*”)) OR TS= (“drug* safe*”) |
5 | 3844 | ((TS= (“post-marketing surveillance”)) OR TS= (“drug* surveillance program”)) OR TS= (“spontaneous report*”) |
6 | 243,892 | #4 OR #5 |
7 | 1134 | #3 AND #6 |
8 | 1077 | #7 AND Language (English) AND Document Type (Article OR Review) |
9 | 599 | Exclusion of 478 articles not related to pharmacovigilance for rare diseases |