Skip to main content

Table 2 Incidence of chronic symptoms during observation period

From: Clinical features of acute attacks, chronic symptoms, and long-term complications among patients with acute hepatic porphyria in Japan: a real-world claims database study

 

Overall AHP Population,

N (%)

Matched Population,

N (%)

Chronic symptoms (ICD-10)

391

3910

Abdominal pain

  

Pain localized to upper abdomen (R10.1)

17 (4.3)

49 (1.3)

Pelvic and perineal pain (R10.2)

1 (0.3)

8 (0.2)

Pain localized to other parts of lower abdomen (R10.3)

9 (2.3)

62 (1.6)

Other and unspecified abdominal pain (R10.4)

53 (13.6)

143 (3.7)

Muscle pain

  

Myalgia (M79.1)

13 (3.3)

73 (1.9)

Low muscle strength

  

Other symptoms and signs involving nervous and musculoskeletal systems (R29.8)

9 (2.3)

12 (0.3)

Nausea

  

Nausea and vomiting (excluding chemotherapy-induced emesis) (R11 except R11 Z512)

70 (17.9)

318 (8.1)

Fatigue

  

Malaise and fatigue (R53)

7 (1.8)

27 (0.7)

Insomnia

  

Sleep disorders (G47.0)

90 (23.0)

389 (9.9)

Mental disorder

  

Mood [affective] disorders (F30-F39)

42 (10.7)

130 (3.3)

Neurotic, stress-related, and somatoform disorders (F40-F48)

85 (21.7)

261 (6.7)

Behavioral syndromes associated with physiological disturbances and physical factors (F50-F59)

12 (3.1)

24 (0.6)

Mental disorder (details)

  

Manic episode (F30)

0 (0)

0 (0)

Bipolar affective disorder (F31)

6 (1.5)

14 (0.4)

Depressive episode (F32)

35 (9.0)

112 (2.9)

Recurrent depressive disorder (F33)

0 (0)

2 (0.1)

Persistent mood [affective] disorders (F34)

2 (0.5)

12 (0.3)

Other mood [affective] disorders (F38)

0 (0)

1 (0)

Unspecified mood [affective] disorder (F39)

0 (0)

0 (0)

Phobic anxiety disorders (F40)

0 (0)

1 (0)

Other anxiety disorders (F41)

44 (11.3)

133 (3.4)

Obsessive-compulsive disorder (F42)

2 (0.5)

3 (0.1)

Reaction to severe stress, and adjustment disorders (F43)

6 (1.5)

13 (0.3)

Dissociative [conversion] disorders (F44)

15 (3.8)

13 (0.3)

Somatoform disorders (F45)

29 (7.4)

85 (2.2)

Other neurotic disorders (F48)

26 (6.6)

60 (1.5)

Eating disorders (F50)

10 (2.6)

11 (0.3)

Nonorganic sleep disorders (F51)

1 (0.3)

8 (0.2)

Sexual dysfunction, not caused by organic disorder or disease (F52)

0 (0)

2 (0.1)

Mental and behavioral disorders associated with puerperium, not elsewhere classified (F53)

0 (0)

0 (0)

Psychological and behavioral factors associated with disorders or diseases classified elsewhere (F54)

1 (0.3)

3 (0.1)

Abuse of non-dependence-producing substances (F55)

0 (0)

0 (0)

Unspecified behavioral syndromes associated with physiological disturbances and physical factors (F59)

0 (0)

0 (0)

  1. AHP, acute hepatic porphyria; ICD-10, International Classification of Diseases, Tenth Revision; MDV, Medical Data Vision