Skip to main content

Table 2 Scoliosis in OI with respect to clinical subtypes

From: Scoliosis in osteogenesis imperfecta: identifying the genetic and non-genetic factors affecting severity and progression from longitudinal data of 290 patients

 

Extended clinical subtypes

Row summary (% a)

p value

I

III

IV

V

Num of spine radiographic follow-ups

0.19

Only once

16

27

64

10

n = 117 (40.3)

 

Twice

12

12

45

4

n = 73 (25.2)

 

Three times

7

6

25

5

n = 43 (14.8)

 

Four times

1

12

19

1

n = 34 (11.7)

 

More than four times

2

10

9

2

n = 23 (7.9)

 

Scoliosis severity (the max Cobb angle among all follow-ups)

< 0.001

Non-scoliotic (Cobb < 10°)

26

4

50

5

n = 85 (29.3)

 

Mild (Cobb 10°–25°)

13

11

74

8

n = 106 (36.5)

 

Moderate (Cobb 25°–50°)

0

15

22

3

n = 40 (13.8)

 

Severe (Cobb > 50°)

0

37

16

6

n = 59 (20.3)

 

Age of first scoliotic radiographsb

Median age (years)

7.6 ± 4.2

16.1 ± 8.3

11.6 ± 6.6

11.9 ± 6.5

12.7 ± 7.4

 

Onset age-groupb

< 0.001

EOS (< 10 years)c

10

13

50

9

n = 82 (28.3)

 

Before 5

5

4

12

1

n = 22

 

Before 3

1

1

2

0

n = 4

 

LOS (≥ 10 years)d

1

1

13

0

n = 15 (5.2)

 

Unknowne

2

49

49

8

n = 108 (37.2)

 
  1. aOut of 290 patients
  2. bOnly among the 205 patients with scoliosis. Age of first scoliotic radiographs is not the onset age, which usually precedes the latter to an unknown extent. Plus–minus values are means ± SD
  3. cEOS early onset scoliosis
  4. dLOS late onset scoliosis
  5. eAll cases other than early or late onset ones. The unknown group may contain both early and late onset patients