Fig. 5
From: HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction
HDAC5 inhibition activates ERK/EGR1 signaling to regulate MEF2A expression during cardiomyocyte hypertrophy
(A-C) Western blot results and statistical analysis of EGR1, ERK, and p-ERK expression in mice (n = 3 for each group). (D-F) Western blot results and statistical analysis of EGR1, ERK, and p-ERK expression in H9C2 cells (n = 3 for each group). (G-H) Western blot results and statistical analysis of HDAC5, MEF2A, EGR1, ERK, and p-ERK expression in H9C2 cells after transfection with HDAC5 siRNA (n = 3 for each group). Data are presented as means ± SD, *P < 0.05; **P < 0.01