Fig. 3
From: HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction
LMK235 attenuates TAC-induced ventricular remodeling and Ang II-induced H9C2 cell hypertrophy
(A) Representative images of cardiac appearance for each group. (B) Heart weight/body weight (HW/BW) (n = 6 for each group). (C) Hematoxylin and eosin staining in horizontal sections of heart tissue. Scale bar, 50 μm. (D, E) Representative images of Masson’s trichrome staining in each group and statistical analysis of the fibrotic area. Scale bar, 50 μm. (n = 6 for each group). (F, G) Representative images of WGA staining in each group and statistical analysis of cardiomyocytes cross-sectional area. Scale bar, 50 μm. (n > 50 for each group). (H-K) Western blot results and statistical analysis of BNP, ANP, and β-MHC expression in mice (n = 3 for each group). (L-O) Western blot results and statistical analysis of BNP, ANP, and β-MHC expression in H9C2 cells (n = 3 for each group). Data are presented as means ± SD, *P < 0.05; **P < 0.01