Fig. 6

Age of symptom onset, lost benchmarks, and disease management. A Distribution of age of onset for major early onset symptoms among patients in whom these symptoms were reported. B Fraction of patients who did not present with the symptoms in (A). C Distribution of age of onset for major later stage onset symptoms. D Fraction of patients who did not present with the symptoms in (C). F Distribution of age of loss of benchmarks. E Fraction of patients who never achieved benchmarks in (F). (G) Distribution of reported age where disease management devices were first utilized among patients. H Fraction of patients who did not utilize each respective disease management device. A–H Patients not included in this analysis if presentation was reported but age of presentation not provided