Fig. 1

Drawing the clinical picture. The clinical manifestations that present throughout the lifespan of people living with XLH as discussed by the attendees at XLH Matters. Blue indicates the clinical manifestations that first present in early childhood, while orange represents those that manifest in adolescence and adulthood. An increase in colour scale denotes an increasing burden of individual manifestions. ^†Clinical manifestations identified as commonly missed in patients with XLH; ^‡Clinical manifestations identified as challenging to manage in patients with XLH; *Clinical manifestations associated with conventional therapy