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Table 5 Retrospective analysis of joint conditions and orthopaedic surgery by age group

From: The International X-Linked Hypophosphatemia (XLH) Registry: first interim analysis of baseline demographic, genetic and clinical data

Characteristics, n (%)a

Children

1 to < 5 years

Children

5 to < 12 years

Adolescents

12 to < 18 years

Total pediatric participants

Adults 18 to < 30 years

Adults 30 to < 50 years

Adults ≥ 50 years

Total adult participants

Total

Joint conditions (osteoarthritis)

n = 2

n = 2

n = 2

N = 6

n = 7

n = 14

n = 19

N = 40

N = 46

 Neck

0

0

0

0

0

0

3 (15.8)

3 (7.5)

3 (6.5)

 Spine

0

0

1 (50.0)

1 (16.7)

0

3 (21.4)

3 (15.8)

6 (15.0)

7 (15.2)

 Shoulder

0

0

0

0

2 (28.6)

2 (14.3)

5 (26.3)

9 (22.5)

9 (19.6)

 Wrist

1 (50.0)

1 (50.0)

0

2 (33.3)

1 (14.3)

0

1 (5.3)

2 (5.0)

4 (8.7)

 Hip

0

1 (50.0)

0

1 (16.7)

1 (14.3)

5 (35.7)

11 (57.9)

17 (42.5)

18 (39.1)

 Knee

1 (50.0)

0

1 (50.0)

2 (33.3)

5 (71.4)

8 (57.1)

11 (57.9)

24 (60.0)

26 (56.5)

 Ankle

0

1 (50.0)

0

1 (16.7)

2 (28.6)

0

3 (15.8)

5 (12.5)

6 (13.0)

 Foot

0

1 (50.0)

0

1 (16.7)

0

0

0

0

1 (2.2)

Orthopedic surgery

n = 3

n = 18

n = 31

N = 52

n = 26

n = 39

n = 34

N = 99

N = 151

 Craniotomy/craniectomy

1 (33.3)

1 (5.6)

6 (19.4)

8 (15.4)

0

1 (2.6)

0

1 (1.0)

9 (6.0)

 Stapling of growth plates

0

14 (77.8)

13 (41.9)

27 (51.9)

5 (19.2)

0

2 (5.9)

7 (7.1)

34 (22.5)

 Fracture fixation (plates/screws)

0

0

4 (12.9)

4 (7.7)

0

4 (10.3)

3 (8.8)

7 (7.1)

11 (7.3)

 Fracture fixation (nails/rods)

0

0

2 (6.5)

2 (3.8)

1 (3.8)

3 (7.7)

4 (11.8)

8 (8.1)

10 (6.6)

 Fracture fixation, external

0

0

2 (6.5)

2 (3.8)

2 (7.7)

2 (5.1)

1 (2.9)

5 (5.1)

7 (4.6)

 Hip replacement

0

0

0

0

0

4 (10.3)

10 (29.4)

14 (14.1)

14 (9.3)

 Knee replacement

0

0

0

0

1 (3.8)

0

8 (23.5)

9 (9.1)

9 (6.0)

 Ankle replacement

0

0

0

0

0

1 (2.6)

2 (5.9)

3 (3.0)

3 (2.0)

Osteotomy

2 (66.7)

5 (27.8)

12 (38.7)

19 (36.5)

21 (80.8)

32 (82.1)

17 (50.0)

70 (70.7)

89 (58.9)

 Tibial torsion/club foot correction

0

1 (5.6)

1 (3.2)

2 (3.8)

0

0

0

0

2 (1.3)

 Leg lengthening

0

 

2 (6.5)

2 (3.8)

3 (11.5)

2 (5.1)

0

5 (5.1)

7 (4.6)

  1. N represents number of participants in the main categories: total pediatric participants, total adult participants and total participants. n represents the number of participants in the age groups within the main categories
  2. Percentage denominators are the number of participants for whom data was reported in that category
  3. aNo joint conditions data were available for infants (< 1 year; n = 5)