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Table 2 Retrospective analysis of bone conditions and fractures by age group

From: The International X-Linked Hypophosphatemia (XLH) Registry: first interim analysis of baseline demographic, genetic and clinical data

Characteristics, n (%)

Children

1 to < 5 years

Children

5 to < 12 years

Adolescents

12 to < 18 years

Total pediatric participants

Adults

18 to < 30 years

Adults

30 to < 50 years

Adults

≥ 50 years

Total adult participants

Total

Bone conditionsa

n = 33

n = 112

n = 78

N = 223

n = 23

n = 36

n = 20

N = 79

N = 304

 Genu varum

27 (81.8)

74 (66.1)

42 (53.8)

143 (64.1)

15 (65.2)

17 (47.2)

10 (50.0)

42 (53.2)

187 (61.5)

 Genu valgum

1 (3.0)

47 (42.0)

30 (38.5)

78 (35.0)

9 (39.1)

6 (16.7)

6 (30.0)

21 (26.6)

99 (32.6)

 Craniosynostosis

3 (9.1)

24 (21.4)

18 (23.1)

45 (20.2)

0

2 (5.6)

1 (5.0)

3 (3.8)

48 (15.9)

 Rachitic rosary

4 (12.1)

13 (11.6)

5 (6.4)

22 (9.9)

2 (8.7)

1 (2.8)

0

3 (3.8)

25 (8.2)

 Chiari malformation

3 (9.1)

3 (2.7)

2 (2.6)

8 (3.6)

0

0

0

0

8 (2.6)

Bone fractures

n = 1

n = 3

n = 5

N = 9

n = 4

n = 18

n = 19

N = 41

N = 50

 Ribs

0

0

1 (20.0)

1 (11.1)

0

1 (5.6)

2 (10.5)

3 (7.3)

4 (8.0)

 Spine

0

0

0

0

0

0

3 (15.8)

3 (7.3)

3 (6.0)

 Forearm

0

0

0

0

0

2 (11.1)

0

2 (4.9)

2 (4.0)

 Hand/wrist/fingers

1 (100)

0

1 (20.0)

2 (22.2)

0

2 (11.1)

4 (21.1)

6 (14.6)

8 (16.0)

 Hips

0

0

0

0

1 (25.0)

1 (5.6)

3 (15.8)

5 (12.2)

5 (10.0)

 Femur

0

0

2 (40.0)

2 (22.2)

2 (50.0)

10 (55.6)

10 (52.6)

22 (53.7)

24 (48.0)

 Tibia/fibula

0

2 (66.7)

1 (20.0)

3 (33.3)

1 (25.0)

6 (33.3)

4 (21.1)

11 (26.8)

14 (28.0)

 Ankle

0

0

0

0

0

2 (11.1)

0

2 (4.9)

2 (4.0)

 Feet

0

0

0

0

0

1 (5.6)

1 (5.3)

2 (4.9)

2 (4.0)

 Upper arm

0

1 (33.3)

0

1 (11.1)

0

1 (5.6)

0

1 (2.4)

2 (4.0)

 Pelvis

0

0

0

0

0

1 (5.6)

0

1 (2.4)

1 (2.0)

  1. N represents number of participants in the main categories: total pediatric participants, total adult participants and total participants. n represents the number of participants in the age groups within the main categories
  2. Percentage denominators are the number of participants for whom data was reported in that category
  3. aNo bone or fracture data were available for infants (< 1 year of age; n = 5). These items were reported by adults as occurring in their childhood