Table 3 Association of variables with death and loss of autonomy in EPM2A- and NHLRC1-related LD combined: multivariable Cox regression analysis
Variables | Death (n = 250) | Loss of autonomy (n = 116) | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
NHLRC1: MS/MS and MS/PT | Reference | – | Reference | – |
NHLRC1: PT/PT | 2.88 (1.23–6.78) | 0.015 | 2.03 (0.75–5.56) | 0.17 |
EPM2A: MS/MS and MS/PT and PT/PT | 1.51 (1.10–6.39) | 0.34 | 0.60 (0.18–2.07) | 0.42 |
Age at onset 18 + versus < 18 years | 0.26 (0.07–0.96) | 0.043 | 0.25 (0.06–1.05) | 0.058 |
Geographic origin | ||||
Asian versus European | 2.63 (1.07–6.49) | 0.036 | 2.80 (1.06–7.42) | 0.038 |
African versus European | 4.30 (0.66–28.0) | 0.13 | 7.18 (0.28–183) | 0.23 |
American versus European | 2.18 (0.73–6.5) | 0.16 | 1.57 (0.61–4.02) | 0.35 |