Table 2 Association of variables with death and loss of autonomy in EPM2A and NHLRC1-related LD: multivariable analysis
Variables | Death (n = 109) | Loss of autonomy (n = 52) | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
EPM2A | ||||
MS/MS | Reference | - | Reference | - |
MS/PT | 0.37 (0.06–2.03) | 0.25 | 0.27 (0.07–1.09) | 0.066 |
PT/PT | 0.58 (0.21–1.62) | 0.29 | 0.74 (0.34–1.64) | 0.46 |
Age at onset 18 + versus < 18 years | 0.65 (0.10–4.29) | 0.66 | 4.16 (0.87–19) | 0.073 |
Geographic origin | ||||
Asian versus European | 7.60 (2.62–22.0) | < 0.001 | 4.83 (1.58–14.9) | 0.006 |
African versus European | –* | – | –* | – |
American versus European | 3.91 (1.26–12.2) | 0.018 | 2.70 (0.90–8.11) | 0.076 |
Variables | Death (n = 141) | Loss of autonomy (n = 64) | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
NHLRC1 | ||||
MS/MS | Reference | – | Reference | – |
MS/PT | 0.56 (0.12–2.68) | 0.47 | 1.24 (0.46–3.32) | 0.68 |
PT/PT | 2.66 (1.10–6.39) | 0.029 | 2.12 (1.04–4.31) | 0.038 |
Age at onset 18 + versus < 18 years | 0.20 (0.02–1.69) | 0.14 | 0.41 (0.10–1.76) | 0.23 |
Geographic origin | ||||
Asian versus European | 1.17 (0.31–4.37) | 0.82 | 1.10 (0.15–7.82) | 0.93 |
African versus European | 3.78 (0.21–67.2) | 0.37 | 9.23 (0.24–354) | 0.23 |
American versus European | 0.86 (0.07–10.5) | 0.91 | 0.82 (0.12–5.36) | 0.83 |