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Table 4 The top five nodes in mc_GPBN #0 ranked by five centralities

From: Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma

 

Degree

Closeness

Betweenness

Eigenvector

PageRank

1

X-linked Adreno-

leukodystrophy; ABCD1 WT;

VK-0214

Abnormal Eye

X-linked Adreno-

leukodystrophy; ABCD1 WT; VK-0214

X-linked Adreno-

leukodystrophy; ABCD1 WT; VK-0214

X-linked Adreno-

leukodystrophy; ABCD1 WT; VK-0214

2

Autosomal Dominant Leukodystrophy with Autonomic Disease; LMNB1

X-linked Adreno-

leukodystrophy; ABCD1 WT; VK-0214

Autosomal Dominant Leukodystrophy with Autonomic Disease; LMNB1

Attention Deficit Hyperactivity Disorder (ADHD)

Paraparesis

3

Muscle Spasticity

Autosomal Dominant Leukodystrophy with Autonomic Disease; LMNB1

Paraparesis

Vision impairment or loss

Facial Abnormality

4

Paraparesis

Progressive Disorder

Muscle Spasticity

Hearing Impairment

Autosomal Dominant Leukodystrophy with Autonomic Disease; LMNB1

5

Cognitive Decline/

Impairment

Muscle Spasticity

Cerebro-medullospinal Disconnection

Dementias, Amentia

ABCD1 Gene