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Table 2 EBV DNA loads and EBV-specific antibodies before sintilimab treatment

From: Sintilimab treatment for chronic active Epstein–Barr virus infection and Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in children

Case

EBV DNA loads (copies/ml)

EBV specific antibody

Peripheral blood

Plasma

Bone marrow

Viral capsid antigen IgG antibody

Capsid antigen IgG antibody affinity

Viral capsid antigen IgM antibody

Early antigen IgG antibody

Nuclear antigen IgG antibody

1

1.97 × 106

3.15 × 104

2.25 × 105

 + 

High

 + 

 + 

2

1.41 × 107

2.19 × 104

5.34 × 103

 + 

High

 + 

 + 

3

1.11 × 106

2.73 × 103

 + 

High

 +