Table 2 Semiological characteristics of the psychotic episodes in 10 adult NP-C patients
Psychosis | Delusions | Other associated symptoms | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient ID | age at psychosis | Psychosis at onset | Age at Miglustat (Mgst) | Psychotic relapse | Age at last follow-up | Follow-up of psychotic patients after diagnosis | Types of delusions | Systematization | Visual hallucinations | Auditory hallucinations | Consciously perceived Hallucinations | Delirium | Agitation | Derealisation | Anosognosia | Discordance |
1 | 23 | − | 22 | − | 36 | NA | None | − | 1 | 0 | − | − | + | − | − | + |
2 | 18 | − | 22 | − | 34 | 12 | Persecution, megalomania | − | 0 | 0 | NA | + | + | + | + | + |
3 | 23 | − | 23 | − | 32 | 9 | Persecution, culpability | − | 1 | 1 | NA | + | + | + | + | − |
4 | 16 | + | 32 | − | 38 | 6 | Persecution, prejudice, culpability | − | 1 | 1 | − | + | + | − | + | + |
5 | 16 | + | No Mgst | + | 40 | 16 | Persecution | − | 1 | 1 | − | + | + | NA | + | + |
6 | 18 | + | No Mgst | + | 50 | 17 | Persecution* | − | NA | 1 | − | + | + | + | + | + |
7 | 21 | − | 23 | − | 24 | 1 | Persecution | − | 1 | 0 | − | + | + | + | + | + |
8 | 20 | + | 25 | + (toxic use) | 33 | 8 | Persecution, megalomania, filiation, mystic | − | 0 | 1 | − | − | + | − | + | + |
9 | 25 | + | 27 | + | 36 | 9 | None | − | 0 | 1 | − | + | + | + | + | + |
10 | 30 | + | No Mgst | + | 57 | 16 | Persecution, jealousy, prejudice, culpability | − | 0 | 1 | NA | + | + | + | + | + |
Means or percentage | 21.00 | 60 (6/10) | 24.86 | 50 (5/10) | 38.00 | 10.44 | 0 (0/10) | 55 (5/9) | 70 (7/10) | 0 (0/7) | 80 (8/10) | 100 (10/10) | 66 (6/9) | 90 (9/10) | 90 (9/10) | |
Associated thymic symptoms | Associated behavoural symptoms | Psychotropic treatments | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Depressive symptoms | Anxiety symptoms | Emotional Hyper reactivity | Excessive Spending | Impaired social cognition | Affective blunting | Desinhibition | Social retreat | Apathy | Stereotypies | Number of treatments prior to diagnosis | number of treatments at last follow-up | AP efficacy | AP Intolerance |
+ | + | + | − | + | + | − | + | + | NA | 0 (0) | 0 (0) | NR | NR |
+ | + | + | + | + | + | + | − | − | NA | 5 (2) | 2 (0) | 0 | NA |
+ | + | + | − | NA | − | + | + | + | NA | 3 (1) | 2 (0) | 1 | NA |
+ | + | + | + | NA | NA | + | + | + | NA | 13 (5) | 5 (2) | 0 | NA |
− | − | − | − | + | − | + | + | + | + | 5 (2) | 4 (2) | 0 | NA |
+ | NA | + | NA | NA | NA | NA | NA | + | NA | 13 (4) | NA | 0 | NA |
+ | + | + | + | + | + | − | + | + | + | 4 (2) | 1 (1) | 0 | NA |
− | − | − | + | + | + | + | + | + | + | 8 (6) | 2 (2) | 0 | 0 |
+ | − | − | + | + | − | + | + | + | + | 9 (5) | NA | 0 | 1 |
+ | NA | + | − | + | − | + | + | + | NA | 12 (6) | NA | 0 | NA |
80 (8/10) | 66 (6/9) | 70 (7/10) | 55 (5/9) | 100 (7/7) | 50 (4/8) | 77 (7/9) | 88 (8/9) | 90 (9/10) | 100 (4/4) | 7,2 (3,3) | 2,3 (1) | 11 (1/9) | 50 (1/2) |