Fig. 2
From: Pathogenic mechanisms of osteogenesis imperfecta, evidence for classification
Bone mineralization disorders & osteoblastic differentiation and functional defects
OASIS: old astrocyte-specific inducible substance; S1P, S2P: endopeptidases on the Golgi apparatus that together form the Regulatory Intramembrane Protein Hydrolysis System (RIP); WNT1: a secreted ligand; LRP5/6: low-density lipoprotein receptor-related protein 5/6; Frizzled: receptor on the cell membrane, a seventh transmembrane protein; BMP: bone morphogenetic protein.