Total choline intake and working memory performance in adults with phenylketonuria

Table 5 Comparison of characteristics between participants with and without IDC data from 6 to 11 years of age^a

	With IDC (n = 30)	Without IDC (n = 10)	P-value^b
Female, n (%)	9 (30)	2 (20)	0.70
Age (years)	25 (21, 30)	25 (21, 33)	0.94
Education (years)	16.0 (14.0, 17.0)	15.0 (15.0, 16.0)	0.69
BMI (kg/m²)	27.1 (22.7, 29.7)	24.8 (23.2, 28.3)	0.86
Intellectual Ability (Matrix Reasoning Score)	11.0 (9.0, 13.0)	10.0 (7.0, 12.0)	0.43
Most Recent Phe (µmol/L)	384.0 (239.6, 597.7)	335.8 (296.4, 574.1)	0.94
Total Protein Intake (g/d)	74.9 (61.1, 88.4)	67.1 (54.7, 90.6)	0.66
Medical Food Protein (g/d)	22.4 (15.8, 35.8)	23.8 (16.7, 32.0)	0.38
Intact Protein (g/d)	50.0 (38.4, 66.0)	42.0 (18.0, 60.0)	0.75
Total Fat (g/d)	60.2 (50.7, 87.4)	62.6 (46.9, 76.5)	0.94
Total Choline (mg/d)	255.1 (180.6, 510.0)	308.0 (196.8, 671.2)	0.51
Total Vitamin B12 (mcg/d)	5.4 (2.8, 11.4)	7.8 (5.2, 12.7)	0.18
Total Vitamin B6 (mg/d)	3.1 (2.0, 11.3)	3.7 (2.6, 3.9)	0.63
Total Folate (mcg DFE/d)	1083.3 (704.7, 1353.9)	1290.3 (1080.4, 1597.2)	0.16
Total Methionine + Cysteine (mg/d)	2216.7 (1676.0, 2767.7)	2091.7 (1610.3, 3093.3)	0.79
Adherence to Medical Food RX^c	1.1 (0.8, 1.0)	1.0 (1.0, 1.0)	0.96
Adherence to Intact Protein RX^d	1.8 (1.1, 2.2)	1.6 (1.2, 3.3)	0.72
Sapropterin Dihydrochloride Treatment, n (%)	16 (53.3)	6 (60.0)	1.00

^aContinuous variables are reported as median (IQR) and categorical variables are reported as frequency (%)
^bp-values were derived from the Mann–Whitney U test for continuous variables and the Fisher Exact Test for categorical variables
^cCalculated as the ratio of medical food protein equivalents consumed to medical food protein equivalents prescribed. Calculated for n = 28 for ‘With IDC’ group and n = 9 for ‘Without IDC’ group. Two participants with IDC and one participant without IDC did not have medical food prescriptions
^dCalculated as the ratio of intact protein (g) consumed to intact protein (g) prescribed

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