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Table 4 Multivariate regression results of treatment regimens effect for two subgroups of hemophilia severity

From: Treatment regimens, patient reported outcomes and health-related quality of life in children with moderate and severe hemophilia A in China: using real-world data

Variables

Annual bleeds (AME)

Chronic pain (OR)

Target joints (AME)

Disability (OR)

EQ-5D (AME)

EQ-VAS (AME)

 

Moderate

Severe

Moderate

Severe

Moderate

Severe

Moderate

Severe

Moderate

Severe

Moderate

Severe

Treatment regimens (vs. On-demand)

Short-term prophylaxis

-32.78**

-38.68***

0.45*

0.29***

0.20

0.14

0.12

0.77

0.16**

0.05**

11.29**

5.56*

Long-term prophylaxis

-61.06***

-49.67***

0.03**

0.11***

0.11

-0.39

1.00

1.00

0.18***

0.07**

18.02**

12.18*

Age (vs. 0–4)

5–9

-9.75

2.27

6.07***

3.60***

0.55*

0.62***

1.00

3.24

0.01

0.03

-11.02*

4.32

10–14

-10.99

8.55

1.49*

4.19***

1.00**

1.45***

1.00

9.58**

0.01

0.06

-6.4

2.18

15–18

-8.02

2.72

15.41**

22.60***

1.20**

2.03***

0.08

58.93***

-0.05

-0.09

-15.25*

-10.36*

BMI (vs. Underweight)

Normal

9.60

1.25

1.17

0.84

0.02

0.06

0.23

0.64

-0.02

0.01

-2.75

2.06

Overweight

-14.32

11.30

2.16

1.13

0.15

0.88**

1.00

1.23

-0.03

-0.03

-10.24*

-2.52

Social health insurance (vs. Yes)

No

1.87

5.45

0.28

0.82

0.28

-0.14

1.00

1.00

0.12

-0.02

6.94

-2.24

Regional location (vs. East area)

Mid area

4.41

6.95

1.27

2.65***

0.01

0.50**

1.22

1.27

-0.09

-0.04*

-11.63*

0.97

West area

-18.24

0.71

3.16

2.90***

0.55

0.36*

1.00

1.57

-0.11

-0.03

-10.23*

-6.23

Infectious blood disease (vs. No)

Yes

2.90

-3.49

0.02**

1.46

-0.66*

0.20

1.00

1.00

0.15

-0.08

22.59***

-10.57

  1. AME, average marginal effect; OR, odds ratio. The results of 95% CI are omitted due to the limited room
  2. *p < 0 0.05. **p < 0 0.01. ***p < 0 0.001