Table 3 Multivariate regression results of treatment regimens effect on patient-reported outcomes and HRQoL.

Treatment regimens (vs. On-demand)

Short-term prophylaxis

-37.62***

-52.91 to -22.33

0.34***

0.21 to 0.55

-0.10

-0.21 to 0.40

0.58

0.23 to 1.64

0.08**

0.02 to 0.14

6.63*

0.10 to 13.26

Long-term prophylaxis

-52.27***

-79.26 to -34.28

0.08***

0.02 to 0.27

-0.27

-0.63 to 0.09

1.00

NA

0.12**

0.03 to 0.20

14.69*

2.32 to 27.06

Age (vs. 0–4)

5–9

0.31

-10.50 to 11.11

3.63***

2.18 to 6.06

0.62***

0.35 to 0.89

2.79

0.26 to 29.27

0.03

-0.01 to 0.07

-0.57

-6.43 to 5.38

10–14

3.17

-10.34 to 16.67

3.09***

1.77 to 5.39

1.31***

0.91 to 1.71

10.64*

1.24 to 90.93

0.05*

0.01 to 0.09

0.64

-5.97 to 7.25

15–18

3.66

-10.66 to 17.97

16.20***

7.91 to 33.18

1.84***

1.27 to 2.41

92.16***

8.20 to 103.55

-0.07

-0.17 to 0.03

-9.61*

-18.91 to -0.30

BMI (vs. Underweight)

Normal

3.24

-6.97 to 13.45

0.93

0.60 to 1.44

0.06

-0.20 to 0.32

0.53

0.13 to 2.02

0.01

-0.04 to 0.04

0.08

-5.23 to 5.40

Overweight

4.77

-7.72 to 17.27

1.30

0.67 to 2.50

0.69*

0.15 to 1.23

0.74

0.14 to 3.73

-0.04

-0.10 to 0.02

-5.03

-13.27 to 3.21

Social health insurance (vs. Yes)

No

2.17

-19.55 to 23.89

0.66

0.34 to 1.30

0.04

-0.80 to 0.89

1.00

NA

0.01

-0.09 to 0.10

-1.38

-13.40 to 10.64

Regional location (vs. East area)

Mid area

7.00

-4.15 to 18.14

2.38**

1.40 to 4.07

0.41*

0.05 to 0.76

1.28

0.35 to 4.62

-0.06**

-0.10 to -0.01

-3.10

-9.11 to 2.90

West area

-4.24

-15.00 to 6.53

2.96***

1.79 to 4.89

0.47**

0.12 to 0.82

1.16

0.32 to 4.09

-0.06*

-0.11 to -0.01

-3.04

-9.52 to 3.44

Hemophilia severity (vs. Moderate)

Severe

2.63

-14.17 to 8.90

0.89

0.55 to 1.44

0.28

-0.03 to 0.59

2.75

0.82 to 9.22

0.01

-0.02 to 0.04

2.96

-2.27 to 8.20

Infectious blood disease (vs. No)

Yes

-3.61

-21.11 to 77.84

0.51

0.15 to 1.71

-0.06

-0.55 to 0.44

1.00

NA

-0.02

-0.12 to 0.09

-0.59

-14.27 to 13.08