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Table 7 Change from baseline in VABS-II ABC scores by baseline age and DAS-II GCA score subgroups

From: Neurodevelopmental status and adaptive behavior of pediatric patients with mucopolysaccharidosis II: a longitudinal observational study

 

Patient subgroup

 

Baseline age

< 7 years

(n = 42)

Baseline age

≥ 7 years

(n = 13)

Baseline DAS-II GCA score ≤ 70

(n = 18)

Baseline DAS-II GCA score > 70

(n = 26)

Baseline

    

 n

41

12

18

24

 Mean (SD)

83.9 (15.12)

82.9 (11.14)

73.8 (7.00)

90.3 (14.73)

Change from baseline at month 12

    

 n

20

9

7

19

 Mean (SD)

−4.0 (7.64)

1.0 (6.84)

−2.4 (5.83)

−0.9 (7.30)

Change from baseline at month 24

    

 n

13

8

5

14

 Mean (SD)

−4.4 (8.42)

1.9 (6.06)

−2.8 (4.09)

−1.8 (9.63)

  1. Changes from baseline were calculated using data only from patients with data available at both baseline and month 12 or at both baseline and month 24
  2. For VABS-II: mean = 100; standard scores of ≤ 70, 71–85, and 86–114 indicate a low, moderately low, and adequate adaptive level, respectively
  3. ABC, Adaptive Behavior Composite; DAS-II, Differential Ability Scales, Second Edition; GCA, General Conceptual Ability; SD, standard deviation; VABS-II, Vineland Adaptive Behavior Scales, Second Edition
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172