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Table 4 DAS-II standard scores and changes from baseline in the overall study population

From: Neurodevelopmental status and adaptive behavior of pediatric patients with mucopolysaccharidosis II: a longitudinal observational study

 

DAS-II standard scores (n = 54)

 

Cluster

Composite

 

Verbal

Nonverbal

Spatial

GCA

SNC

Baseline

     

 n

46

45

35

44

34

 Mean (SD)

80.1 (17.46)

86.0 (14.52)

77.6 (20.56)

78.4 (19.11)

78.8 (18.23)

Change from baseline at month 12

     

 n

28

27

22

27

21

 Mean (SD)

−1.1 (11.67)

4.0 (12.97)

−2.5 (13.98)

−0.9 (9.39)

1.2 (11.18)

Change from baseline at month 24

     

 n

21

20

20

20

19

 Mean (SD)

−6.4 (17.66)

−5.3 (16.81)

−3.9 (18.19)

−3.8 (12.71)

−5.4 (16.43)

  1. Changes from baseline were calculated using data only from patients with data available at both baseline and month 12 or at both baseline and month 24
  2. For DAS-II cluster and composite scores: mean = 100; standard scores of ≤ 69, 70–79, 80–89, and 90–109 indicate very low, low, below average, and average function, respectively
  3. DAS-II, Differential Ability Scales, Second Edition; GCA, General Conceptual Ability; SD, standard deviation; SNC, special nonverbal composite
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172