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Table 1 The performance of the Langbehn formulas and the ML models to predict the AAO using participants with a narrow (n: 41–56) and wider (w: 36–59) CAG repeat size (caghigh)

From: Machine learning in Huntington’s disease: exploring the Enroll-HD dataset for prognosis and driving capability prediction

Model

MAE

RMSE

R2

n

w

n

w

n

w

LGBM

5.26

5.46

6.87

7.16

0.60

0.63

CatBoost

5.29

5.49

6.91

7.20

0.60

0.62

Linear regression

5.45

5.77

7.07

7.50

0.58

0.59

Langbehn refitted

5.38

5.74

7.09

7.57

0.58

0.58

MLP

5.46

5.77

7.14

7.55

0.57

0.58

XGBoost

5.48

5.65

7.15

7.41

0.57

0.60

Langbehn

5.57

5.91

7.23

7.88

0.56

0.55

Linear SVM

5.68

5.96

7.35

7.75

0.55

0.56

Random forest

5.85

6.03

7.63

7.89

0.51

0.55

Knn

6.18

6.37

8.11

8.37

0.45

0.49