Table 1 Inclusion and exclusion criteria for patients with PFAPA
Inclusion criteria | Exclusion criteria |
|---|---|
Fulfil the modified Marshall criteria of PFAPA [1]: I. Regularly recurring fevers with an early onset (< 5 years of age) II. Constitutional symptoms in the absence of upper respiratory infection with at least 1 of the following clinical signs: (a) Aphthous stomatitis (b) Cervical lymphadenitis (c) Pharyngitis III. Exclusion of cyclic neutropenia IV. Completely asymptomatic between episodes V. Normal growth and development Duration of fever episodes less than 7 days Age up to 7 years at the time of inclusion | In association with fever episodes had any of the following: Skin rash Arthritis Severe abdominal pain Diarrhoea Thoracic pain Spleen enlargement Sensorineural hearing impairment Cold-induced symptoms Unable to understand written Swedish |