Fig. 5

Schematic diagram of core features of the CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP) and brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS). Both disorders are on the same continuum, albeit differ in the severity of CSF1R mutations’ consequences and phenotypes. WMLs – white matter lesions