Table 4 Clinical features and 24 h blood pressure monitoring according to tumor burden (number of cutaneous neurofibromas and presence of a plexiform neurofibroma) in Neurofibromatosis type 1 patients
From: Blunted circadian variation of blood pressure in individuals with neurofibromatosis type 1
Cutaneous neurofibromas | Plexiform neurofibromas | ||||||
|---|---|---|---|---|---|---|---|
0 | 1–49 | ≥ 50 | p-value | No | Yes | p-value | |
N (%) | 4 (17) | 16 (66) | 4 (17) | 16 (67) | 8 (33) | ||
Age, y | 28.0 (21.0–43.0) | 38.0 (27.0–54.0) | 51.0 (38.0–56.0) | 0.251 | 39.0 (28.5–52.0) | 35.5 (25.0–54.5) | 0.854 |
Men, n (%) | 3 (75.0) | 6 (37.5) | 1 (25.0) | 0.301 | 7 (43.8) | 3 (37.5) | 0.770 |
BMI, Kg/m2 | 21.9 (19.8–24.3) | 24.0 (20.4–25.8) | 24.3 (20.6–27.2) | 0.641 | 23.7 (19.5–25.6) | 24.4 (21.5–26.6) | 0.478 |
Casual SBP mmHg | 105.0 (95.0-115.0) | 107.0 (95.0-110.0) | 100.0 (95.0-115.0) | 0.907 | 109.0 (100.0-115.0) | 100.0 (90.0-108.0) | 0.276 |
Casual DBP mmHg | 65.0 (55.0–70.0) | 60.0 (60.0–70.0) | 60.0 (60.0–65.0) | 0.949 | 65.0 (60.0–70.0) | 60.0 (57.5–64.5) | 0.211 |
Casual PR | 80.5 (69.5–89.0) | 76.0 (69.5–81.5) | 75.0 (74.0–80.0) | 0.887 | 74.0 (66.0–80.0) | 80.0 (75.0-84.5) | 0.112 |
ABPM | |||||||
24 h-SBP mmHg | 113.0 (107.5–116.0) | 110.0 (102.5-115.5) | 110.5 (102.0-119.2) | 0.865 | 113.5 (107.0-116.0) | 107.0 (99.0-110.5) | 0.085 |
24 h-DBP mmHg | 70.5 (69.0-72.5) | 68.5 (65.5–73.0) | 72 (65.0-77.3) | 0.754 | 70.5 (67.5–73.5) | 68.0 (65.0-72.5) | 0.443 |
24 h-PR | 66.5 (63.5–77.5) | 79.0 (69.0–83.0) | 73.9 (69.5–84.9) | 0.521 | 70.5 (66.5–82.8) | 81.0 (72.5–83.5) | 0.358 |
Daytime SBP mmHg | 114.0 (110.0-118.0) | 114.5 (106.0-119.5) | 111.5 (101.5-122.7) | 0.938 | 116.0 (110.0-120.5) | 106.0 (103.0-113.0) | 0.070 |
Daytime DBP mmHg | 74.5 (73.0-76.5) | 71.5 (68.5–76.5) | 72.5 (67.0-78.7) | 0.553 | 73.0 (70.0–78.0) | 71.5 (68.5–74.0) | 0.407 |
Daytime PR | 70.0 (65.0-82.5) | 80.5 (70.0–89.0) | 77.0 (71.0-88.5) | 0.718 | 72.0 (69.0-87.5) | 83.0 (73.0-89.5) | 0.481 |
Nocturnal SBP mmHg | 107.0 (103.0-111.5) | 102.5 (97.5–109.0) | 108.5 (102.0-113.3) | 0.543 | 105.5 (100.5-110.7) | 104.0 (96.5–109.0) | 0.646 |
Nocturnal DBP mmHg | 63.5 (62.0–65.0) | 63.0 (59.5–68.0) | 68.6 (61.5–74.1) | 0.684 | 63.5 (61.5–68.0) | 62.0 (59.0–71.0) | 0.713 |
Nocturnal PR | 61.0 (60.5–69.5) | 72.5 (63.5–77.5) | 70.2 (66.5–78.7) | 0.473 | 66.0 (61.0-75.4) | 74.0 (70.5–78.0) | 0.177 |
Systolic decline (%) | 6.4 (3.2–8.7) | 9.9 (8.3–13.1) | 3.4 (0.5–7.7) | 0.049 | 9.9 (8.1–12.5) | 2.8 (0.9–8.7) | 0.020 |
Diastolic decline (%) | 13.6 (12.3–16.1) | 14.7 (11.5–19.1) | 8.2 (4.0-10.8) | 0.072 | 14.1 (12.8–18.8) | 9.6 (8.1–14.9) | 0.098 |
PR decline (%) | 12.8 (6.6–15.6) | 10.3 (6.7–14.2 ) | 10.8 (6.5–14.5) | 0.967 | 12.4 (8.4–14.3) | 7.4 (5.4–15.7) | 0.327 |