Table 1 Clinical features and circadian rhythm pattern of blood pressure in Neurofibromatosis type 1 patients
From: Blunted circadian variation of blood pressure in individuals with neurofibromatosis type 1
Total median (IQR) | Dipper median (IQR) | Non-dipper median (IQR) | Riser median (IQR) | p-value | |
|---|---|---|---|---|---|
n = 24 | n = 8 (33%) | n = 12 (50%) | n = 4 (17%) | ||
Age, y | 38,5 (26.5–53.5) | 44.0 (30.5–53.5) | 34.5 (25.0–54.0) | 33.5 (23.5–48.0) | 0.709 |
Men, n (%) | 10 (41.7) | 3 (37.5) | 4 (33.3) | 3 (75.0) | 0.328 |
BMI (Kg/m2) | 23.8 (20.1–25.8) | 23.7 (20.4–25.6) | 23.9 (20.4–25.8) | 22.5 (18.7–26.8) | 0.944 |
Casual SBP mmHg | 105.5 (95.0-110.0) | 110.0 (110.0 -120.0) | 100.0 (90.0 -109.0) | 100.0 (95.0 -103.0) | 0.085 |
Casual DBP mmHg | 60.0 (60.0–70.0) | 70.0 (60.0–75.0) | 60.0 (60.0–70.0) | 60.0 (55.0-64.5) | 0.244 |
Casual PR bpm | 75.0 (72.0–83.0) | 80.0 (65.5–87.5) | 75.0 (72.0–80.0) | 76.5 (72.5–88.5) | 0.839 |
ABPM | |||||
24 h-SBP mmHg | 110.5 (104.5–116.0) | 113.5 (110.5–116.0) | 107.5 (99.0-116.0) | 109.0 (107.0-117.5) | 0.443 |
24 h-DBP mmHg | 69.5 (66.5–73.5) | 71.0 (67.5–75.0) | 68.5 (64.5–71.0) | 71.5 (68.0–74.0) | 0.563 |
24 h-PR bpm | 73.9 (67.0–83.0) | 76.0 (69.0-85.3) | 69.5 (65.5–79.0) | 83.5 (77.0–89.0) | 0.098 |
Daytime SBP mmHg | 114.5 (106.0-119.5) | 119.0 (116.0-122.0) | 110.0 (103.5-117.5) | 108.0 (106.0-112.0) | 0.076 |
Daytime DBP mmHg | 72.0 (69.5–76.5) | 76.0 (71.5–79.5) | 71.5 (68.0–75.0) | 71.0 (68.0–73.0) | 0.264 |
Daytime PR bpm | 77.0 (69.0–89.0) | 78.5 (71.5–90.5) | 73.5 (67.0-80.5) | 88.0 (76.5–95.0) | 0.197 |
Nocturnal SBP mmHg | 105.0 (99.5-109.2) | 102.5 (101.0-108.0) | 102.5 (96.0-113.3) | 109.0 (107.0-126.0) | 0.249 |
Nocturnal DBP mmHg | 63.5 (60.0–68.0) | 63.0 (59.0–68.0) | 63.5 (60.5–65.0) | 71.0 (62.5–80.5) | 0.362 |
Nocturnal PR bpm | 70.2 (61.5–77.5) | 69.5 (63.5–75.9) | 66.0 (60.5–73.2) | 77.5 (75.0–82.0) | 0.095 |
Systolic decline (%) | 9.5 (5.0-11.1) | 12.1 (10.4–13.7) | 7.6 (5.0-9.5) | 1.0 (0.9-12.14) | 0.003 |
Diastolic decline (%) | 13.5 (9.5–17.0) | 18.6 (14.5–19.3) | 12.8 (8.9–13.7) | 12.0 (4.2–22.3) | 0.030 |
Pulse rate decline (%) | 11.7 (6.8–14.3) | 13.4 (7.7–15.8) | 8.7 (5.4–12.9) | 13.2 (10.7–16.5) | 0.311 |