Fig. 2
From: SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome
A Hematoxylin–Eosin staining of cortical adrenal gland from patient (Pt) and controls (CTR) (10 × magnification). The image shows differences in cytoarchitecture of cortical adrenal zones glomerulosa (g), fasciculata (f) and reticularis (r) in patient’s tissue with areas of atrophy, cellular scarcity and cellular irregularities characterized by fibro-lipidic substitution, especially of the inner layers. B Immunohistochemistry of adrenal gland using Lamin A/C antibody shows irregular shape of nuclear lamina in patient’s cortical zones and a normal staining in the control (20 × magnification). The boxes represent a higher magnification further highlighting the aberrant nuclear membrane shape in patient’s sample