Fig. 5From: Novel pathogenic NPR2 variants in short stature patients and the therapeutic response to rhGHFunctional characterization of the NPR2 variants. HEK293T cells were transiently transfected with wild-type or mutant (Leu527Phe) NPR2, or both, and were incubated with CNP (100 µM, 30 min). Whole-cell cGMP contents were quantified by ELISA (n = 5); mean ± SD shown; *p < 0.05, ** p < 0.01, ***p < 0.001 by t-testBack to article page