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Table 5 Treatment and outcome in patients with CNS actinomycosis

From: The epidemiology, clinical presentation and treatment outcomes in CNS actinomycosis: a systematic review of reported cases

Variables

N (%)

Mean antimicrobial duration (days)

160

Antibiotic treatment

 

Single

61/104 (58.7)

Combination antimicrobials

43/104 (41.3)

Not specified

14

Type of antimicrobial therapy

 

1. Penicillin based regimen

47

Penicillin alone

20

Combination with other antibioticsa

27

2. Ceftriaxone based regimen

29

Ceftriaxone alone

3

Combination with other antibioticsb

26

3. Ampicillin based regimen

11

Ampicilllin. Alone

4

Combination of other antibioticsc

7

4. Meropenem

5

Outcome

 

Patient died

13/118 (11)

Survived with sequelae

17/77 (22)

Survived without sequelae

60/77 (78)

  1. aother antibiotics = cotrimoxazole/amoxicillin/doxycycline
  2. bother antibiotics = ciprofloxacin/amoxicillin/clindamycin/erythromycin
  3. cother antibiotics = doxycycline/clindamycin/amoxicillin,