Achondroplasia natural history study (CLARITY): 60-year experience in orthopedic surgery from four skeletal dysplasia centers

Table 2 Risk factors for the first orthopaedic surgery

	Spine surgery		Lower extremity surgery		Both spine and lower extremity surgery
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Gender (male:female)	1.12 (0.82–1.54)	0.48	1.11 (0.85–1.44)	0.44	1.12 (0.89–1.41)	0.35
CMD	1.85 (1.30–2.63)	< 0.01	0.96 (0.69–1.32)	0.80	1.10 (0.83–1.46)	0.50
Hydrocephalus requiring shunt	1.97 (1.14–3.26)	= 0.01	1.46 (0.89–2.31)	0.118	1.95 (1.28–2.97)	< 0.01
CMD and hydrocephalus requiring shunt (on different dates)	2.26(1.11–4.28)	= 0.017	1.93 (1.04–3.46)	0.031	2.38 (1.35–4.18)	< 0.01
OSA on CPAP	1.42 (0.90–2.24)	0.13	1.32 (0.90–1.93)	0.16	1.50 (1.06–2.12)	0.02
Lower extremity surgery	2.05 (1.45–2.90)	< 0.01	–	–	–	–
Spine surgery	–	–	2.05 (1.45–2.90)	< 0.01	–	–
Height	1.03 (1.02–1.03)	< 0.001	0.99 (0.99–1.00)	0.149	1.01 (1.00–1.01)	0.027
Weight	1.04 (1.02–1.05)	< 0.001	0.98 (0.96–1.00)	0.023	1.01 (1.00–1.02)	0.034
OFC	1.06 (1.02–1.09)	< 0.001	0.98 (0.96–1.00)	0.050	1.00 (0.98–1.02)	0.826

ISSN: 1750-1172