Achondroplasia natural history study (CLARITY): 60-year experience in orthopedic surgery from four skeletal dysplasia centers

Table 1 Types of orthopedic surgeries performed

	Number of procedures	Number of subjects *		Age, years**
	Number of procedures	With at least one procedure	With multiple procedures	Mean ± SD	Median (minimum–maximum)
Any orthopaedic procedure	1109	408	299	13.7±12.7	9.9 (0.1–62.7)
Both spine and lower extremity procedure	267	58	58	13.8 ± 11.4	12.8 (1.1–57.8)
Spine procedures	425	175	116	22.4±15.3	16.7 (0.1–67.4)
Any laminectomy	235	126	54	25.5±115.6	20.6 (0.1–67.6)
Cervical laminectomy (below C2)	38	29	6	24.6 ± 18.3	21.0 (0.1–64.4)
Thoracic laminectomy	92	67	16	27.3 ± 16.5	21.7 (3.4–65.8)
Lumbosacral laminectomy	141	109	22	26.7 ± 15.2	23.8 (2.0–67.4)
Spinal fusion	142	106	24	21.0 ± 15.1	15.6 (0.8–65.8)
Other	12	11	1	13.0 ± 11.2	11.5 (3.1–42.4)
Lower extremity procedures	684	291	199	9.9±8.3	8.2(0.2–57.8)
Osteotomy	434	200	163	9.1 ± 5.8	7.9 (1.1–36.9)
Tension band plating for guided growth	27	23	4	8.6 ± 2.9	8.9 (4.0–12.3)
Fibulectomy	26	22	4	6.3 ± 2.4	6.0 (2.5–11.4)
Limb lengthening	24	17	5	9.9 ± 5.0	9.6 (0.2–20.5)
Epiphysiodesis	13	11	1	7.8 ± 2.9	7.6 (4.0–12.4)
Hip replacement	4	3	1	46.1 ± 7.6	42.4 (41.1–54.8)
Implant removal	87	73	11	9.9 ± 5.1	10.7 (2.4–27.8)
Other	69	58	9	15.3±12.4	13.6(1.0–57.8)

^*The procedures are not mutually exclusive, SD, standard deviation
^**Ages are for first time procedures
The types of spine and lower extremity procedures performed are displayed with the number of patients undergoing at least one of these procedures and the number of patients undergoing multiple procedures. Decompression was the most common spine surgery, and osteotomy was the most common lower extremity surgery. The age at which the first surgery was performed is also demonstrated. Spine procedures were performed later in life compared to lower extremity procedures

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