Fig. 2From: New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic reviewPresumed pathophysiology of PAM. Alveolar type II cell in the alveolus of the lung. Dysfunctional sodium-phosphate co-transporter (NaPi-2b) in the apical membrane leading to a decreased cell uptake of phosphate from the alveolar space and deposition of calcium-phosphate stones (microliths) due to chelationBack to article page