French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes

Box 7 Key differentiating features between HES and EGPA in patients with hypereosinophilic asthma and systemic manifestations

	ANCA-positive EGPA	ANCA-negative EGPA	HES
ANCA	Positive (almost exclusively MPO)	Absent	Absent
Asthma	Present	Present	Possible
Cardiac involvement	Rare	Common	Possible
Extra-capillary glomerulonephritis	Possible	Absent	Absent
Alveolar hemorrhage	Possible	Absent	Absent
Peripheral neurological presentation	Predominantly single or multiple mononeuropathy	Predominantly polyneuropathy	Predominantly polyneuropathy
Scleritis	Possible	Absent	Absent
Vasculitis	Present	Present	Possible
CRP	Elevated	Variable	Low (except for thrombosis and severe eosinophilic myocarditis)

ISSN: 1750-1172