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Box 4 Main investigations to be performed in case of persistent unexplained HE > 1.5 × 109/L

From: French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes

CBC

Serum electrolytes, creatinine

Complete liver function tests

LDH, CPK 

Serum calcium and phosphorus

Troponin, BNP

Serum protein electrophoresis

Serum tryptase

Vitamin B12

Total IgE

CRP

HIV serology

Toxocara serology

Other serology for parasitic infection and HTLV-1 depending on the context

Parasitological examination of the stool (Baermann method if strongyloidiasis is suspected)

CT of the chest, abdomen, and pelvis

  1. In the absence of a cause and in case of persistent HE, ECG and transthoracic echocardiography should also be performed.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172