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Fig. 14 | Orphanet Journal of Rare Diseases

Fig. 14

From: Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Fig. 14

Effect of α-LA on protein lipoylation levels on induced neurons (iNs). Control and PKAN iNs (P1) were treated with α-LA at 10 μM for 15 days a Representative images of protein lipoylation levels in α-LA treated and untreated control and P1 PKAN iNs. Scale bar = 15 μm. b Quantification of fluorescence intensity by FIJI-ImageJ. iNs showed positive immunoreactivity against Tau. Data represent the mean ± SD of 50 cell images for each condition. ***p < 0.0001between PKAN patients and controls. ###p < 0.001 between untreated and treated fibroblasts. A.U., arbitrary units

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172