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Table 2 Performance of agglomerative hierarchical clustering models: according to response to elamipretide. Performance metrics of three agglomerative hierarchical clustering models in clustering 10 participants with respect to their response to elamipretide for each of the outcomes. 5XSST, 5 times sit-to-stand test; 6MWT, 6-minute walking test; BTHS-SA, Barth Syndrome Symptom Assessment; HHD, handheld dynamometry; MLCL:CL, monolysocardiolipin to cardiolipin ratio; PROMIS, Patient-Reported Outcomes Measurement Information System; PV, physiological variable

From: Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data

Outcome measure

True Negative

False Positive

False Negative

True Positive

Accuracy

(%)

Number of PVs

6MWT

5

0

0

5

100

143

PROMIS Fatigue score

5

0

0

5

100

109

SWAY Balance score

5

0

0

5

100

122

BTHS-SA Total Fatigue

5

0

0

5

100

115

Muscle Strength by HHD

5

0

0

5

100

129

5XSST

5

0

0

5

100

117

MLCL:CL

5

0

0

5

100

143