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Table 1 Performance of agglomerative hierarchical clustering models: according to functional status. Performance metrics of three agglomerative hierarchical clustering models in clustering 30 observations (3 visits in 10 participants) with respect to their outcome value. 5XSST, 5 times sit-to-stand test; 6MWT, 6-minute walking test; BTHS-SA, Barth Syndrome Symptom Assessment; HHD, handheld dynamometry; MLCL:CL, monolysocardiolipin to cardiolipin ratio; PROMIS, Patient-Reported Outcomes Measurement Information System; PV, physiological variable

From: Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data

Outcome measure

True Negative

False Positive

False Negative

True Positive

Accuracy

(%)

Number of PVs

6MWT

14

1

1

14

93

205

PROMIS Fatigue score

13

2

2

13

87

195

SWAY Balance score

12

3

3

12

80

232

BTHS-SA Total Fatigue

9

6

6

9

60

214

Muscle Strength by HHD

9

6

6

9

60

271

5XSST

11

4

4

11

73

244

MLCL:CL

10

5

5

10

67

167