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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data

Fig. 3

Clustering patients according to response to elamipretide. Agglomerative hierarchical clustering with standardized Euclidean distance metric and complete linkage method. Clustermap of 10 participants interfaced with PVs based on their similarity mapped into responders and non-responders groups to drug elamipretide. Clustermap of PVs with outcomes (A) 6MWT, (B) PROMIS fatigue score, (C) SWAY balance score, (D) BTHS-SA, (E) Muscle strength by HHD, (F) 5XSST, (G) MLCL:CL. 5XSST, 5 times sit-to-stand test; 6MWT, 6-minute walking test; BTHS-SA, Barth Syndrome Symptom Assessment; HHD, handheld dynamometry; MLCL:CL, monolysocardiolipin to cardiolipin ratio; PROMIS, Patient-Reported Outcomes Measurement Information System; PV, physiological variable

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172