Fig. 1

Clustering patients according to functional status. Agglomerative hierarchical clustering with standardized Euclidean distance metric and complete linkage method. Clustermap of 30 participants interfaced with PVs based on their similarity mapped into two groups below and above median value of each of the 7 outcomes: (A) 6MWT, (B) PROMIS fatigue score, (C) SWAY balance score, (D) BTHS-SA, (E) Muscle strength by HHD, (F) 5XSST, and (G) MLCL:CL. Yellow dotted line area in (A) represent the set of PVs with high expression level of similarity only for one group of functional status. 5XSST, 5 times sit-to-stand test; 6MWT, 6-minute walking test; BTHS-SA, Barth Syndrome Symptom Assessment; HHD, handheld dynamometry; MLCL:CL, monolysocardiolipin to cardiolipin ratio; PROMIS, Patient-Reported Outcomes Measurement Information System; PV, physiological variable