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Table 2 Comorbidities and most frequent symptoms causing main discomfort

From: Psychological distress of adult patients consulting a center for rare and undiagnosed diseases: a cross-sectional study

Most common comorbidities reported by patients (n = 142)

n (%)

10 symptoms most frequently mentioned as main discomfort1 (n = 130)

n (%)

Allergies/ intolerances

71 (50.4)

Fatigue

37 (28.5)

Thyroid disease

48 (34.0)

Loss of productivity

28 (21.5)

Diseases of the skeletal system

47 (33.3)

Pain arms, hands, legs, feet

24 (18.5)

Respiratory disease

41 (29.1)

Muscular pain

20 (15.4)

Diseases of the digestive system

36 (25.5)

Joint pain

14 (10.8)

Eye disease

33 (23.4)

Irritation of the skin

14 (10.8)

Disease of the circulatory system

29 (20.6)

Muscle weakness

13 (10.0)

Renal and urinary tract disease

25 (17.7)

Stomachache

12 (9.2)

Neurological disease

25 (17.7)

Headache

12 (9.2)

Psychological disorder

24 (17.0)

Increased need for sleep

12 (9.2)

Heart disease

21 (14.9)

Dyspnea

11 (8.5)

Blood disease

20 (14.2)

  

Metabolic disease

18 (12.8)

  

Diseases of the muscular system

13 (9.2)

  

Liver disease

8 (5.7)

  
  1. 1 Patients were asked to name 3 symptoms mainly causing discomfort