Table 2 Excess weight reported in individual studies
From: Overweight and obesity in adult patients with phenylketonuria: a systematic review
First author, year | Sample size | PKU gender | Mean/median BMI (kg/m2) | Overweight frequency (%) | Obesity frequency (%) | PR (95% CI) | Trend (p value) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
PKU | Controls | Males | Females | PKU | Controls | PKU | Controls | PKU (female/male) | Controls | |||
Azabdaftari, 2019 [8] | 23 | 28 | 13 | 10 | 27.6 ± 5.4 | 23.4 ± 6.4 | 19 | NR | 33 (50/18) | NR | NA | p < 0.001 |
Burton, 2018 [14] | 3691 | 18455 | 1341 | 2350 | NR | NR | 5.35 | 2.25 | NR | NR | 2.06 | p < 0.0001 |
Trefz, 2019 [15] | 377 | 3770 | 158 | 219 | NR | NR | 15.9* | 11.2* | * | * | 1.43 (1.11–1.83) | Signifcantly different |
Robertson, 2013 [9] | 236 | NA | 115 | 121 | 26 ± 5.4 | NA | 31 | NA | 24 (34/17) | NA | NA | Similar to background population |
Jani, 2017 [16] | 27 | NA | 9 | 18 | 27.1 | NA | NR | NA | NR | NA | NA | Slightly higher than background population |
Ozel, 2014 [17] | 164 | NA | 63 | 101 | NR | NA | 15.2–42 | NA | 4.5–24.2 | NA | NA | Less or similar to background population |
Couce,# 2018 [19] | 41# | 25# | 17# | 24# | NR | NR | 35.9# | 12.9# | 17.9# | 22.5# | NA | NA |
Williams, 2015 [18] | 41 | NA | 15 | 26 | 30.3 ± 1.8 | NA | 14 | NA | 72 | NA | NA | NA |