From: The burden of illness in Lennox–Gastaut syndrome: a systematic literature review
PICOS | Inclusion | Exclusion |
---|---|---|
Population | Patients with LGS, including clearly defined “probable” LGS | Other DEEs |
Intervention | Studies assessing the overall burden of illness of LGS without the impact of an intervention | Studies assessing the impact of interventionsa |
Comparator | N/A | – |
Outcomes | Prevalence/incidence Economic burden Direct and indirect costs Resource use Patient and caregiver HRQoL and broader patient-reported outcomes Mortality | – |
Study designs/publication type | Publications reporting original data, including: Healthcare insurance claims data Chart reviews Registry studies Electronic healthcare databases studies Epidemiologic surveys Observational studies Economic evaluations if they contain original data on resource utilisation and HRQoL | In vitro and in vivo studies Preclinical studies Case reports and case series Clinical studies reporting only efficacy and safety data Economic evaluations reporting on specific interventionsb Reviewsc, SLRsc, comments, letters, editorials and press releases |
Limits | Searches of conferences in Embase were limited to the previous 3 years (conferences 2018-current)d | None |