Fig 3
From: The burden of illness in Lennox–Gastaut syndrome: a systematic literature review
Adapted from: Reaven et al (2018) [54], Piña-Garza et al (2017) [46], Stockl et al (2019) [55], Hollenack et al (2019) [52], Reaven et al (2019) [53] and Strzelczyk et al (2021) [47] .* Costs were converted from Euros to US dollars on 21st June 2022 (exchange rate 1.00 Euro =1.06 US Dollars [xe.com]). ASM, anti-seizure medication; DS, Dravet syndrome; ED, emergency department; LGS, Lennox–Gastaut syndrome; PPPY, per person per year; OP, outpatient; TSC, tuberous sclerosis complex
A Total direct costs in LGS patients (blue) versus control patients (grey), patients with other epilepsies (lilac), and in LGS patients with seizure events vs without seizure events and LGS patients in years where patients were prescribed with rescue medication vs years where patients were not prescribed rescue medication (blue) B resource utilization and costs in LGS patients vs controls; C resource utilization and costs in LGS patients with seizure events vs without seizure events.