Table 2 The stability analysis of mutations by different servers and software
Mutation (kcal/mol) | ΔΔG DynaMut | ΔΔG ENCoM | ΔΔG mCSM | ΔΔG SDM | ΔΔG DUET | ΔΔG FoldX |
|---|---|---|---|---|---|---|
KIF21A F355S |  − 1.974 |  − 0.998 |  − 1.709 |  − 1.400 |  − 1.717 | 3.006 |
Destabilizing | Destabilizing | Destabilizing | Destabilizing | Destabilizing | Destabilizing | |
CHN1 H217R |  − 0.395 | 0.021 |  − 1.270 |  − 0.390 |  − 1.108 | 0.204 |
Destabilizing | Destabilizing | Destabilizing | Destabilizing | Destabilizing | Stabilizing | |
TUBB3 S78T |  − 0.066 |  − 0.063 |  − 0.206 | 0.090 | 0.227 |  − 0.4751 |
Destabilizing | Destabilizing | Destabilizing | Stabilizing | Stabilizing | Stabilizing |