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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial

Fig. 1

Schematic representation of homocysteine metabolism. 5, 10-methylene-THF: 5,10-methylene-tetrahydrofolate; 5-Me-THF: 5-methyl-tetrahydrofolate; BHMT: betaine homocysteine methyl transferase; CBS: cystathionine beta synthase; MTHFR: methylene-tetrahydrofolate reductase; methylcblc: methylcobalamin; MS: methionine synthase; MSR: methionine synthase reductase; PLP: pyridoxal phosphate; THF: tetrahydrofolate; SAM: S-adenosylmethionine; SAH:S-adenosylhomocysteine

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172