Fig. 4

Sex differences in force plate actimeter results. Cln8^mnd males weighed significantly more than Cln8^mnd females at 2, 4, 6, and 8 months of age and started losing weight at 6 months of age (A). No consistent differences were observed in distance travelled (B), bouts of low mobility (C), or area covered (D). Cln8^mnd males exhibited greater frequency of focused stereotypy at 2, 4, 6, and 8 months of age (E). Comparisons of tremor scores revealed that Cln8^mnd females had higher tremor scores than their male counterparts at frequencies 15–20 Hz and 20–25 Hz (F–I). Comparisons of wild type males versus wild type females^{^}, Cln8^mnd males versus Cln8^mnd females*, Cln8^mnd males versus wild type males^#, and Cln8^mnd females versus wild type females^#. Two-way ANOVA with Fisher’s LSD post-hoc. Mean ± SEM, n = 1–11 animals/sex/group, detailed n described in Additional file 4: Table S1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001